Multiple sclerosis (MS) is the most common inflammatory disease of the central nervous system (CNS), affecting almost 3 million people globally. MS is considered an autoimmune disease believed to be caused by a mix of genetic vulnerability, deficient immune systems, and environmental factors. The body’s immune response is misdirected. As a result Myelin, the fatty substance that coats and protects nerve fibers in the brain and spinal cord, is destroyed. The disease is often unpredictable and can lead to permanent neurological disability.
Researchers have long suspected that autoantigens can trigger Multiple Sclerosis. An antigen is a molecule or molecular structure that can bind to an antibody or T-cell structure. The presence of antigens in the body may trigger an immune response. Our immune cells normally attack intruding bacteria and viruses. But in MS, immune cells target the nervous system instead. This is known as an autoantigen or self-antigen.
Autoantigens could help researchers understand what aspects of the immune system Multiple Sclerosis is targeting. Recently, researchers have discovered four new autoantigens. Identifying these molecules is essential not only for obtaining clues to MS pathogenesis but also for improving the diagnosis and treatment of the condition. While this hasn’t been tested yet, it might be possible to increase the immune system’s tolerance for some antigens so the disease’s effects are reduced. Doctors could screen for autoreactive responses and create individual immunological response profiles. As a result, patients can have a personalized assessment and adjust treatment accordingly.
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At Binder & Binder, we have represented hundreds of clients suffering with Multiple Sclerosis. If you’re unable to work due to any disability, we can help you at Binder & Binder. Please complete a free survey at https://www.binderandbinder.com/free-ssd-evaluation/ and we will contact you shortly with more information on how we can help.